KLHL12 and DRD4

Number of citations of the paper that reports this interaction (PubMedID 18303015)
29

Data Source:
HPRD (in vivo, two hybrid)

		KLHL12	DRD4
Description		kelch like family member 12	dopamine receptor D4
Image
GO Annotations	Cellular Component	Golgi Membrane Cytosol COPII Vesicle Coat COPII-coated ER To Golgi Transport Vesicle Cul3-RING Ubiquitin Ligase Complex Centriolar Satellite Intracellular Membrane-bounded Organelle	Cell Plasma Membrane Integral Component Of Plasma Membrane Membrane Dendrite Postsynapse Glutamatergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding	Dopamine Neurotransmitter Receptor Activity, Coupled Via Gi/Go G Protein-coupled Receptor Activity Dopamine Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Drug Binding Potassium Channel Regulator Activity SH3 Domain Binding Neurotransmitter Receptor Activity Dopamine Binding Identical Protein Binding Metal Ion Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	Protein Monoubiquitination ER To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Wnt Signaling Pathway COPII Vesicle Coating Negative Regulation Of Canonical Wnt Signaling Pathway	Activation Of MAPK Activity Behavioral Fear Response Synaptic Transmission, Dopaminergic Response To Amphetamine Cellular Calcium Ion Homeostasis G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Chemical Synaptic Transmission Adult Locomotory Behavior Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Kinase Activity Response To Histamine Social Behavior Regulation Of Dopamine Metabolic Process Dopamine Metabolic Process Fear Response Regulation Of Circadian Rhythm Behavioral Response To Cocaine Behavioral Response To Ethanol Rhythmic Process Arachidonic Acid Secretion Negative Regulation Of Protein Secretion Positive Regulation Of Dopamine Uptake Involved In Synaptic Transmission Inhibitory Postsynaptic Potential G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Degradation of DVL	Dopamine receptors G alpha (i) signalling events
Drugs			Ziprasidone Cabergoline Ropinirole Olanzapine Clozapine Thiethylperazine Loxapine Remoxipride Pramipexole Promazine Chlorpromazine Amoxapine Lisuride Apomorphine Risperidone Propiomazine Dopamine Pergolide Bromocriptine Quetiapine Levodopa Aripiprazole Paliperidone Methotrimeprazine Flibanserin Iloperidone Rotigotine Asenapine Perospirone Pardoprunox
Diseases
GWAS
Interacting Genes		46 interacting genes: ARAF ATXN1 BAG6 C1QTNF2 CARD10 CCBE1 COL8A1 CPSF6 CRTC3 CUL3 DGCR6 DRD4 DVL2 DVL3 FBXL17 FGD2 FLNA GLYCTK INMT KHSRP KLHL2 KLHL3 LNX1 MED28 MPP1 MRPL10 MTNR1A NDC80 NTAQ1 PDGFRB PEA15 PEF1 PRR13 RIT1 RPP25L SDCBP SEC31A SNX20 SYNE4 TAOK2 TBC1D10C TTBK2 UBE2I VEGFB VTA1 ZBP1	6 interacting genes: CLIC6 GABRA1 GRB2 KCNJ9 KLHL12 NCK1
Entrez ID		59349	1815
HPRD ID		13925	00541
Ensembl ID		ENSG00000117153	ENSG00000069696
Uniprot IDs		Q53G59 Q9H7R2	P21917
PDB IDs		2VPJ	5WIU 5WIV
Enriched GO Terms of Interacting Partners?
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