AEBP2 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 16431907)
45

Data Source:
BioGRID (pull down)

		AEBP2	H1-2
Description		AE binding protein 2	H1.2 linker histone, cluster member
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleoplasm ESC/E(Z) Complex	Nucleosome Nuclear Chromatin Nucleus Nuclear Euchromatin Transcriptionally Active Chromatin
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Metal Ion Binding	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic	Negative Regulation Of Transcription By RNA Polymerase II Nucleosome Assembly Regulation Of Transcription, DNA-templated Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Histone H3-K4 Trimethylation Histone H3-K27 Trimethylation
Pathways		PRC2 methylates histones and DNA PKMTs methylate histone lysines	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		11 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 LDOC1 RALYL RBBP4 SUZ12 THAP1	30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1
Entrez ID		121536	3006
HPRD ID		16477	07514
Ensembl ID		ENSG00000139154	ENSG00000187837
Uniprot IDs		Q6ZN18	P16403
PDB IDs		5WAI 5Y0U 5Y1U 6C23 6C24
Enriched GO Terms of Interacting Partners?
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