USP21 and OTUB2

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		USP21	OTUB2
Description		ubiquitin specific peptidase 21	OTU deubiquitinase, ubiquitin aldehyde binding 2
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleus
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated	Protein Deubiquitination Protein K11-linked Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Ovarian tumor domain proteases
Drugs
Diseases
GWAS
Interacting Genes		54 interacting genes: ATXN3 AURKA BAP1 BRCA2 CBL CBLC DTX3 ESPL1 EXOSC10 FOXM1 H2AC18 ISG15 JOSD1 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350	35 interacting genes: APP ARRDC3 CPSF6 FAM168A GLI2 KRT31 KRT40 LZTS2 MAGEA11 MID1 MID2 PJA1 RBCK1 REL RFFL RNF126 SIAH1 TP53BP2 TRAF6 TRIM2 TRIM25 TRIM26 TRIM27 TRIM39 TRIM5 TRIM54 TRIM55 TRIM63 TRIM8 TRIP6 U2AF2 UBC UBE2N USP21 USP28
Entrez ID		27005	78990
HPRD ID		05291	07620
Ensembl ID		ENSG00000143258	ENSG00000089723
Uniprot IDs		Q9UK80	Q96DC9
PDB IDs		2Y5B 3I3T 3MTN	1TFF 4FJV
Enriched GO Terms of Interacting Partners?
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