USP21 and JOSD1

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		USP21	JOSD1
Description		ubiquitin specific peptidase 21	Josephin domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Cytosol Plasma Membrane Membrane
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Thiol-dependent Ubiquitinyl Hydrolase Activity Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Neuron Projection Development Positive Regulation Of Transcription, DNA-templated	Protein Deubiquitination
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	Josephin domain DUBs
Drugs
Diseases
GWAS			Resting heart rate ( 27798624) Sleep duration ( 30846698)
Interacting Genes		54 interacting genes: ATXN3 AURKA BAP1 BRCA2 CBL CBLC DTX3 ESPL1 EXOSC10 FOXM1 H2AC18 ISG15 JOSD1 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350	21 interacting genes: KRT31 KRT40 KRTAP10-3 KRTAP10-4 KRTAP10-8 KRTAP5-9 KRTAP9-2 LNX1 MID2 NOTCH2NLA PJA1 STUB1 TRAF1 TRIM23 TRIM27 TRIM54 TRIM63 UBC USP15 USP21 USP28
Entrez ID		27005	9929
HPRD ID		05291	08823
Ensembl ID		ENSG00000143258	ENSG00000100221
Uniprot IDs		Q9UK80	A0A024R1P5 Q15040
PDB IDs		2Y5B 3I3T 3MTN
Enriched GO Terms of Interacting Partners?
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