USP7 and PPL

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		USP7	PPL
Description		ubiquitin specific peptidase 7	periplakin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytosol Nuclear Body PML Body Protein-containing Complex	Cornified Envelope Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Extracellular Exosome
	Molecular Function	P53 Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitinyl Hydrolase Activity Lys48-specific Deubiquitinase Activity	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Regulation Of Gluconeogenesis Transcription-coupled Nucleotide-excision Repair Ubiquitin-dependent Protein Catabolic Process Multicellular Organism Development Maintenance Of DNA Methylation Viral Process Protein Ubiquitination Protein Deubiquitination Regulation Of Protein Stability Negative Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Regulation Of Circadian Rhythm Rhythmic Process Protein Stabilization Regulation Of DNA-binding Transcription Factor Activity Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Telomere Capping	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		Ub-specific processing proteases Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Regulation of TP53 Degradation Synthesis of active ubiquitin: roles of E1 and E2 enzymes Regulation of PTEN localization	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Chronotype ( 30696823) Platelet count ( 27863252) Platelet distribution width ( 27863252)	Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)
Interacting Genes		99 interacting genes: ABRAXAS2 ACD ANXA1 ARNT2 ATXN1 BCOR BEND5 CBX8 CHEK1 CLSPN CREB3L3 CRY1 CSNK2A1 CTNNB1 DAXX DNAJA3 DNMT3A EWSR1 EZH2 FOXN2 GATA1 H2AC20 H2BU1 HECW1 HERPUD1 HIF1A HTRA2 HUWE1 IFNAR1 KAT5 KDM1A KLHL8 MAGEE1 MAL MARCHF7 MCMBP MDM2 MDM4 MYC MYD88 NECAB2 NOTCH1 OTUD4 PCGF2 PEG3 PEPD PHF8 PHLDB2 PICK1 PLA2G2A PLEKHO1 POLH PPARG PPL PTEN RAD18 RADIL RARA RB1 RBCK1 RELA RFFL RNF168 RNF220 SCML2 SIRT7 SMAD3 SNCA SUMO2 SYVN1 TANK TBCB TFIP11 TMPO TP53 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRAF6 TRIM22 TRIM31 TRIM54 TRIM55 TRIM63 TRIM8 TRO UBA52 UBC UBE2D3 UBE2E1 UBE2S USP21 USP28 WWP2 XPC ZMYND8 ZNF423	24 interacting genes: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 LARP1 OPRM1 PPHLN1 PTEN RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1
Entrez ID		7874	5493
HPRD ID		03950	04187
Ensembl ID		ENSG00000187555	ENSG00000118898
Uniprot IDs		B7Z855 B7ZAX6 Q6U8A4 Q93009	O60437
PDB IDs		1NB8 1NBF 1YY6 1YZE 2F1W 2F1X 2F1Y 2F1Z 2FOJ 2FOO 2FOP 2KVR 2XXN 2YLM 3MQR 3MQS 4JJQ 4KG9 4M5W 4M5X 4PYZ 4WPH 4WPI 4YOC 4YSI 4Z96 4Z97 5C56 5C6D 5FWI 5GG4 5J7T 5JTJ 5JTV 5KYB 5KYC 5KYD 5KYE 5KYF 5N9R 5N9T 5NGE 5NGF 5UQV 5UQX 5VS6 5VSB 5VSK 5WHC 6F5H	4Q28
Enriched GO Terms of Interacting Partners?
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