SF1 and GAS7

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		SF1	GAS7
Description		splicing factor 1	growth arrest specific 7
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome Nuclear Body	Cytoplasm Cytoskeleton Plasma Membrane
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Pre-mRNA Branch Point Binding	DNA-binding Transcription Factor Activity Protein Binding Cytoskeletal Protein Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Male Sex Determination Nuclear Body Organization Leydig Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Neuron Differentiation Neuron Projection Morphogenesis
Pathways		mRNA Splicing - Major Pathway
Drugs		Artenimol
Diseases
GWAS		Urate levels ( 21768215)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glaucoma ( 30104761 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)
Interacting Genes		43 interacting genes: APBB1 ATXN1 BCAS2 BCL2 CIAO1 DDX17 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MKRN3 NFKB1 PLSCR1 PRKG1 PRPF40A PSMA3 RBM10 RBM17 RBM4 RBM7 RBPMS SF3A1 SF3B1 SF3B4 TAF15 TCERG1 TRIM23 TRIM69 U2AF2 WBP4 WDR77 WDR83 WWP2 ZNF461	20 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 NCKAP1 NCKAP1L NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2
Entrez ID		7536	8522
HPRD ID		03306	16011
Ensembl ID		ENSG00000168066	ENSG00000007237
Uniprot IDs		A0A024R566 A0A024R572 A0A024R588 A0A024R5D9 B4DX42 Q15637	O60861
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX	2LX7 2YSH
Enriched GO Terms of Interacting Partners?
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