GAS7 and NCKAP1L

Number of citations of the paper that reports this interaction (PubMedID 16055720)
81

Data Source:
BioGRID (pull down)

		GAS7	NCKAP1L
Description		growth arrest specific 7	NCK associated protein 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Secretory Granule Membrane SCAR Complex Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	DNA-binding Transcription Factor Activity Protein Binding Cytoskeletal Protein Binding	GTPase Activator Activity Protein Binding Protein Kinase Activator Activity Protein-containing Complex Binding Rac GTPase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Cell Cycle Arrest Neuron Differentiation Neuron Projection Morphogenesis	Cell Morphogenesis B Cell Homeostasis Myeloid Cell Homeostasis Chemotaxis Cell Migration Maintenance Of Cell Polarity Cell Projection Assembly Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Positive Regulation Of B Cell Proliferation Activation Of Protein Kinase Activity Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Cell Adhesion Mediated By Integrin Erythrocyte Homeostasis Negative Regulation Of Myosin-light-chain-phosphatase Activity Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of T Cell Proliferation Positive Regulation Of Phosphorylation Response To Drug T Cell Homeostasis Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of GTPase Activity Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Erythrocyte Development B Cell Receptor Signaling Pathway Positive Regulation Of Phagocytosis, Engulfment Protein-containing Complex Assembly Actin Polymerization-dependent Cell Motility Positive Regulation Of Neutrophil Chemotaxis
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Glaucoma ( 30104761 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 25173106 24002674 22570627 31798171 29785010 31959993 30054594 28073927 29235454) Medication use (antiglaucoma preparations and miotics) ( 31015401) Proteinuria and chronic kidney disease ( 26420894)	Hip circumference adjusted for BMI ( 28552196) Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: ABI1 ACTA1 APBB1IP ATXN1L CREB3L2 CYFIP1 CYFIP2 DIAPH1 FMNL1 GAPDH KHDRBS1 NCKAP1 NCKAP1L NTAQ1 PACSIN1 RPLP0 SF1 SF3A1 SFPQ WASF2	2 interacting genes: GAS7 PRPF40A
Entrez ID		8522	3071
HPRD ID		16011	00781
Ensembl ID		ENSG00000007237	ENSG00000123338
Uniprot IDs		O60861	P55160
PDB IDs		2LX7 2YSH
Enriched GO Terms of Interacting Partners?
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