SF1 and U2AF2

Number of citations of the paper that reports this interaction (PubMedID 9150140)
173

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		SF1	U2AF2
Description		splicing factor 1	U2 small nuclear RNA auxiliary factor 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Ribosome Nuclear Body	Commitment Complex Prp19 Complex Nucleus Nucleoplasm Spliceosomal Complex Nuclear Speck U2-type Prespliceosome U2AF
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding Zinc Ion Binding Identical Protein Binding Pre-mRNA Branch Point Binding	RNA Binding Protein Binding Poly-pyrimidine Tract Binding Enzyme Binding Pre-mRNA 3'-splice Site Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Spliceosomal Complex Assembly MRNA 3'-splice Site Recognition MRNA Splicing, Via Spliceosome Male Sex Determination Nuclear Body Organization Leydig Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Steroid Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Negative Regulation Of Protein Ubiquitination Positive Regulation Of RNA Splicing Negative Regulation Of MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Artenimol
Diseases
GWAS		Urate levels ( 21768215)	Menopause (age at onset) ( 26414677)
Interacting Genes		43 interacting genes: APBB1 ATXN1 BCAS2 BCL2 CIAO1 DDX17 EWSR1 FAM168A FUS GAS7 HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPUL1 IL7R ILF3 ITCH KRTAP26-1 MKRN3 NFKB1 PLSCR1 PRKG1 PRPF40A PSMA3 RBM10 RBM17 RBM4 RBM7 RBPMS SF3A1 SF3B1 SF3B4 TAF15 TCERG1 TRIM23 TRIM69 U2AF2 WBP4 WDR77 WDR83 WWP2 ZNF461	47 interacting genes: APBB1 ATXN1 BEND7 CCAR1 CHERP CHIC2 CPSF7 DACH1 DDX6 DPPA2 DVL2 EPB41 GEMIN2 GLIS2 HLA-DMA IL7R KHDC4 KHDRBS3 LURAP1 MAP1B OTUB2 PIN1 POLR2A PRPF3 PRPF40A PUF60 QKI RBFOX2 RBM39 RBM4 SAP30BP SCAF11 SF1 SMAD5 SNRPA SRPK1 SRPK2 SRSF1 SRSF11 SUGP1 TCERG1 THAP1 TLE5 TOP1 U2AF1 WT1 ZRSR2
Entrez ID		7536	11338
HPRD ID		03306	01872
Ensembl ID		ENSG00000168066	ENSG00000063244
Uniprot IDs		A0A024R566 A0A024R572 A0A024R588 A0A024R5D9 B4DX42 Q15637	P26368
PDB IDs		1K1G 1O0P 1OPI 2M09 2M0G 4FXW 4FXX	1JMT 1O0P 1OPI 1U2F 2G4B 2HZC 2M0G 2U2F 2YH0 2YH1 3VAF 3VAG 3VAH 3VAI 3VAJ 3VAK 3VAL 3VAM 4FXW 4TU7 4TU8 4TU9 5EV1 5EV2 5EV3 5EV4 5W0G 5W0H
Enriched GO Terms of Interacting Partners?
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