TBX3 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		TBX3	PLEKHF2
Description		T-box transcription factor 3	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Sequence-specific DNA Binding	Protein Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Blood Vessel Development In Utero Embryonic Development Cell Fate Specification Heart Looping Outflow Tract Morphogenesis Atrioventricular Bundle Cell Differentiation Cardiac Chamber Development Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Cell Aging Positive Regulation Of Cell Proliferation Anterior/posterior Axis Specification, Embryo Animal Organ Morphogenesis Specification Of Animal Organ Position Stem Cell Population Maintenance Limbic System Development Male Genitalia Development Female Genitalia Development Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development Luteinizing Hormone Secretion Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Embryonic Digit Morphogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Myoblast Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Follicle-stimulating Hormone Secretion Mesoderm Morphogenesis Roof Of Mouth Development Ventricular Septum Morphogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Placode Formation Cardiac Muscle Cell Fate Commitment Sinoatrial Node Cell Development Cellular Senescence Positive Regulation Of Stem Cell Proliferation	Protein Transport
Pathways
Drugs
Diseases		Ulnar-mammary syndrome; Schinzel syndrome
GWAS		Atrial fibrillation ( 29892015) Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Blood pressure ( 21572416 21909110) Bone mineral density (lumbar spine) in inflammatory bowel disease ( 29603369) Breast cancer ( 29059683) Colorectal cancer ( 23266556) Colorectal cancer or advanced adenoma ( 30510241) Diastolic blood pressure ( 26390057 28135244 19430479 27841878 29403010 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Facial morphology ( 31763980) FEV1 ( 30804560) Global electrical heterogeneity phenotypes ( 29622589) Heel bone mineral density ( 30598549 28869591) Hypertension ( 30487518) Idiopathic dilated cardiomyopathy ( 29495422) Ischemic stroke ( 29531354) Left ventricular QRS voltage ( 27195777) Longevity ( 30294719) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 28166213 26635082 30804560) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Metabolite levels ( 23823483) Methadone dose in opioid dependence ( 28115739) Night sleep phenotypes ( 27126917) Nose morphology ( 29921221) Percent mammographic density ( 22532574) PR interval ( 30679814 30046033 20062060 25035420) PR segment ( 24850809) Prostate-specific antigen levels ( 28139693) QRS complex (12-leadsum) ( 27659466) QRS duration ( 30679814 27577874) Serum prostate-specific antigen levels ( 21160077) Stroke ( 29531354) Systolic blood pressure ( 27841878 29403010 27618452 25249183) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Urate levels in overweight individuals ( 25811787)	Radiation response ( 20923822)
Interacting Genes		5 interacting genes: CA8 PLEKHF2 SIRPA TLE5 TOLLIP	71 interacting genes: ACY3 AIDA AIMP2 APP APPL1 ARL14EP BEND7 BLOC1S6 BSCL2 CAVIN2 CCDC172 CCDC85B CEP44 CGGBP1 CHIC2 DPPA4 DRAP1 DTX2 DUT ESRP1 FBXO28 FHL3 FOXA1 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HEY1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NKG7 NONO NPM2 PDP1 PEX2 PRDM14 PRKAR1A PRPSAP1 RAB39A RABAC1 RADX RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SPEF1 TBX3 TCN2 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z USF1 ZNF250 ZNF263 ZNF398
Entrez ID		6926	79666
HPRD ID		03373	15147
Ensembl ID		ENSG00000135111	ENSG00000175895
Uniprot IDs		A0A024RBL6 A0A024RBQ4 O15119	Q9H8W4
PDB IDs		1H6F
Enriched GO Terms of Interacting Partners?
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