SUMO3 and USP25

Number of citations of the paper that reports this interaction (PubMedID 18538659)
82

Data Source:
BioGRID (pull down)

		SUMO3	USP25
Description		small ubiquitin like modifier 3	ubiquitin specific peptidase 25
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GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body	Nucleus Endoplasmic Reticulum Cytosol
	Molecular Function	Protein Binding Enzyme Binding	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding ATPase Binding
	Biological Process	Protein Sumoylation Negative Regulation Of DNA Binding	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Ub-specific processing proteases
Drugs
Diseases
GWAS		Delirium ( 29631748)	Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		47 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FOS HIPK2 HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1	16 interacting genes: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TNKS UBC UBE2I ZNF426
Entrez ID		6612	29761
HPRD ID		03754	05296
Ensembl ID		ENSG00000184900	ENSG00000155313
Uniprot IDs		P55854	Q9UHP3
PDB IDs		1U4A 2IO1 2MP2 6K5R 6NNQ	2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM
Enriched GO Terms of Interacting Partners?
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