USP25 and MT2A

Number of citations of the paper that reports this interaction (PubMedID 16501887)
15

Data Source:
BioGRID (two hybrid)

		USP25	MT2A
Description		ubiquitin specific peptidase 25	metallothionein 2A
Image
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol	Cell Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding ATPase Binding	Protein Binding Drug Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion
Pathways		Ub-specific processing proteases	Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling
Drugs			Zinc
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		16 interacting genes: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TNKS UBC UBE2I ZNF426	20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25
Entrez ID		29761	4502
HPRD ID		05296	08863
Ensembl ID		ENSG00000155313	ENSG00000125148
Uniprot IDs		Q9UHP3	P02795
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM	1MHU 2MHU
Enriched GO Terms of Interacting Partners?
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