USP25 and RAD23A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		USP25	RAD23A
Description		ubiquitin specific peptidase 25	RAD23 homolog A, nucleotide excision repair protein
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex Centriolar Satellite Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding ATPase Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Kinase Binding Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Proteasome Binding Ubiquitin-specific Protease Binding
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Nucleotide-excision Repair Viral Process Protein Deubiquitination Protein Destabilization Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Cell Cycle
Pathways		Ub-specific processing proteases	Josephin domain DUBs DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		16 interacting genes: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TNKS UBC UBE2I ZNF426	53 interacting genes: A2M ADRM1 ANKRD40 ATXN3 ATXN7 CCNA2 CDC37 CHEK1 CREBBP DBI ECSIT EP300 EWSR1 FILIP1 GTF2H1 HSPB1 IFIT3 IFIT5 LOXL4 MAP3K1 MAST1 MDM2 MINDY3 MPG NEDD8 NGLY1 PDE6D PHAX PI4K2A PRKN PSEN1 PSMC5 PSMD4 RNF115 RNF32 RPN1 SMURF1 SQSTM1 TRAF2 TRAF5 TRIM54 TRIP6 UBB UBC UBE3A UBE4B UBL7 UBQLN4 USP25 VAV2 XPC ZBTB44 ZBTB8A
Entrez ID		29761	5886
HPRD ID		05296	07191
Ensembl ID		ENSG00000155313	ENSG00000179262
Uniprot IDs		Q9UHP3	A0A024R7G8 A8K1J3 P54725
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM	1DV0 1F4I 1IFY 1OQY 1P98 1P9D 1QZE 1TP4 1ZO6 2WYQ 5XBO
Enriched GO Terms of Interacting Partners?
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