SUMO3 and EGLN3

Number of citations of the paper that reports this interaction (PubMedID 25380826)
8

Data Source:
BioGRID (enzymatic study)

		SUMO3	EGLN3
Description		small ubiquitin like modifier 3	egl-9 family hypoxia inducible factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Enzyme Binding	Iron Ion Binding Protein Binding Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, 2-oxoglutarate As One Donor, And Incorporation Of One Atom Each Of Oxygen Into Both Donors L-ascorbic Acid Binding Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Protein Sumoylation Negative Regulation Of DNA Binding	Response To Hypoxia Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Protein Hydroxylation Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Regulation Of Cell Proliferation Regulation Of Neuron Apoptotic Process Oxidation-reduction Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Pathways		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Vitamin C Roxadustat
Diseases
GWAS		Delirium ( 29631748)	Alzheimer's disease (late onset) ( 30820047) Daytime sleep phenotypes ( 27126917) Hematocrit ( 27863252)
Interacting Genes		47 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FOS HIPK2 HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1	25 interacting genes: ABI2 ADRB2 ATF4 EFHC2 EPAS1 EPOR FOXJ2 HIF1A HIF3A IKBKG MAPK1 MAPK7 NCAPH2 OS9 PKM PRPF19 SERTAD1 SIAH2 SRP54 SUMO1 SUMO2 SUMO3 TP53 TTC23L WDR83
Entrez ID		6612	112399
HPRD ID		03754	06972
Ensembl ID		ENSG00000184900	ENSG00000129521
Uniprot IDs		P55854	B3KVT0 F8W1G2 Q3T1B0 Q9H6Z9
PDB IDs		1U4A 2IO1 2MP2 6K5R 6NNQ
Enriched GO Terms of Interacting Partners?
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