USP25 and SENP1

Number of citations of the paper that reports this interaction (PubMedID 18538659)
82

Data Source:
BioGRID (enzymatic study)

		USP25	SENP1
Description		ubiquitin specific peptidase 25	SUMO specific peptidase 1
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol	Nucleus Nucleoplasm Cytoplasm Focal Adhesion Nuclear Membrane
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity Ubiquitin-like Protein-specific Protease Activity Ubiquitin Protein Ligase Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ubiquitin Binding ATPase Binding	Endopeptidase Activity Protein Binding SUMO-specific Protease Activity SUMO-specific Isopeptidase Activity
	Biological Process	Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Negative Regulation Of ERAD Pathway	Proteolysis Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Definitive Erythrocyte Differentiation Protein Sumoylation Protein Desumoylation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Apoptotic Signaling Pathway
Pathways		Ub-specific processing proteases	SUMO is proteolytically processed
Drugs
Diseases
GWAS		Crohn's disease ( 25489960) Metabolite levels ( 23823483) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Panic disorder ( 19165232) Parkinson's disease ( 21738487) QRS complex (12-leadsum) ( 27659466) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Glycated hemoglobin levels ( 28898252) Macular thickness ( 30535121) Rheumatoid arthritis ( 30891314)
Interacting Genes		16 interacting genes: ACTA1 FLNC GAPDH MAGEB4 MT2A RAD23A SENP1 SKIL SUMO1 SUMO2 SUMO3 SYK TNKS UBC UBE2I ZNF426	23 interacting genes: APP CAV3 GCM1 HDAC1 HIPK2 KCNK1 NACC1 PARP1 PIAS3 PIM1 PML PRIM1 RABGAP1 RANBP2 RANGAP1 RPL11 SP100 SUMO1 SUMO2 SUMO3 UBE2K USP25 USP28
Entrez ID		29761	29843
HPRD ID		05296	07153
Ensembl ID		ENSG00000155313	ENSG00000079387
Uniprot IDs		Q9UHP3	Q6N001 Q7Z3G1 Q9P0U3
PDB IDs		2MUX 5GP7 5O71 6H4J 6H4K 6HEL 6HEM	2CKG 2CKH 2G4D 2IY0 2IY1 2IYC 2IYD 2XPH 2XRE 6NNQ
Enriched GO Terms of Interacting Partners?
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