ATXN7 and EFEMP2

Number of citations of the paper that reports this interaction (PubMedID 21078624)
23

Data Source:
BioGRID (two hybrid)

		ATXN7	EFEMP2
Description		ataxin 7	EGF containing fibulin extracellular matrix protein 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	Elastic Fiber Assembly
Pathways		HATs acetylate histones Ub-specific processing proteases	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)	Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458)	Acne (severe) ( 24927181) Birth weight ( 31043758)
Interacting Genes		60 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		6314	30008
HPRD ID		06365	05221
Ensembl ID		ENSG00000163635	ENSG00000172638
Uniprot IDs		O15265 Q9UPD8	A0A024R5G1 O95967 Q9H3D5
PDB IDs		2KKR	2KL7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?