ATXN7 and CEP72

Number of citations of the paper that reports this interaction (PubMedID 21078624)
23

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		ATXN7	CEP72
Description		ataxin 7	centrosomal protein 72
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Centrosome Cytosol Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination Protein Deubiquitination	G2/M Transition Of Mitotic Cell Cycle Spindle Organization Centriole Replication Regulation Of G2/M Transition Of Mitotic Cell Cycle Gamma-tubulin Complex Localization Ciliary Basal Body-plasma Membrane Docking Regulation Of Protein Localization To Centrosome
Pathways		HATs acetylate histones Ub-specific processing proteases	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Schizophrenia ( 28991256 25056061 29483656) Type 2 diabetes ( 30054458)	Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Esophageal adenocarcinoma ( 27527254) Lung disease severity in cystic fibrosis ( 26417704) Obesity-related traits ( 23251661) Ulcerative colitis ( 28067908 20228799) Vincristine-induced peripheral neuropathy in acute lymphoblastic leukemia ( 25710658)
Interacting Genes		60 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	18 interacting genes: ATXN7 CATIP FAM90A1 IGHM KIAA0408 LNX1 MCM10 NME7 PCM1 PIN4 PSMA1 SPATA2 SPATA24 SRSF2 STAMBPL1 ZBTB16 ZNF417 ZNF688
Entrez ID		6314	55722
HPRD ID		06365	07685
Ensembl ID		ENSG00000163635	ENSG00000112877
Uniprot IDs		O15265 Q9UPD8	Q9P209
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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