RNF2 and PCGF6

Number of citations of the paper that reports this interaction (PubMedID 12183370)
24

Data Source:
HPRD (two hybrid, in vitro)

		RNF2	PCGF6
Description		ring finger protein 2	polycomb group ring finger 6
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Germ Cell Development Anterior/posterior Axis Specification Gene Expression Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of G0 To G1 Transition	Negative Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inactivation Of X Chromosome By Genetic Imprinting Negative Regulation Of G0 To G1 Transition
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)	Autism spectrum disorder or schizophrenia ( 28540026) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		55 interacting genes: ABCB1 AMBRA1 AUTS2 BAALC BMI1 CASP3 CASP9 CBX2 CBX4 ERG H2AC18 H2AC20 H2AC4 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SIK1 SMURF2 SSX2 TARDBP TFCP2 TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W USP11 USP19 WASHC1	22 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 PEX10 PNMA1 RAD18 RNF2 SS18L1 TRIM14 UBE2D3 UBE2U USP2 USP21
Entrez ID		6045	84108
HPRD ID		07028	07427
Ensembl ID		ENSG00000121481	ENSG00000156374
Uniprot IDs		Q99496	Q9BYE7
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O	2DJB
Enriched GO Terms of Interacting Partners?
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