PCGF6 and EIF2B2

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		PCGF6	EIF2B2
Description		polycomb group ring finger 6	eukaryotic translation initiation factor 2B subunit beta
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding GTP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inactivation Of X Chromosome By Genetic Imprinting Negative Regulation Of G0 To G1 Transition	Ovarian Follicle Development Translational Initiation Regulation Of Translational Initiation Central Nervous System Development Response To Heat Response To Glucose Oligodendrocyte Development Myelination Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Transcriptional Regulation by E2F6	Recycling of eIF2:GDP
Drugs
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)	Mood instability ( 29187730)
Interacting Genes		22 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 PEX10 PNMA1 RAD18 RNF2 SS18L1 TRIM14 UBE2D3 UBE2U USP2 USP21	12 interacting genes: APP C9orf72 CCT3 CSNK2A2 EIF2B1 EIF2B4 EIF2B5 EIF2S1 MRFAP1L1 NCK1 NPC2 PCGF6
Entrez ID		84108	8892
HPRD ID		07427	05923
Ensembl ID		ENSG00000156374	ENSG00000119718
Uniprot IDs		Q9BYE7	P49770 Q53XC2
PDB IDs		2DJB	6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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