RNF2 and CBX2

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology)

		RNF2	CBX2
Description		ring finger protein 2	chromobox 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex	Euchromatin Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity RING-like Zinc Finger Domain Binding	DNA Binding Chromatin Binding Protein Binding Methylated Histone Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Gastrulation With Mouth Forming Second Germ Cell Development Anterior/posterior Axis Specification Gene Expression Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of G0 To G1 Transition	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Differentiation Development Of Primary Sexual Characteristics
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases			46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Clopidogrel active metabolite levels ( 28207573) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661)
Interacting Genes		55 interacting genes: ABCB1 AMBRA1 AUTS2 BAALC BMI1 CASP3 CASP9 CBX2 CBX4 ERG H2AC18 H2AC20 H2AC4 H3-4 KAT8 KMT2A MBD1 MTNR1A OTUD6A PCGF2 PCGF6 PGP PHB2 PHC1 PHC2 PLK1 PSMC4 RING1 RRM1 RYBP SIK1 SMURF2 SSX2 TARDBP TFCP2 TSC22D2 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W USP11 USP19 WASHC1	15 interacting genes: DHX57 H3-4 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP2-4 KRTAP4-12 MDFI PCGF2 PHC2 RBMY1A1 RBMY1F RNF2 RYBP
Entrez ID		6045	84733
HPRD ID		07028	14397
Ensembl ID		ENSG00000121481	ENSG00000173894
Uniprot IDs		Q99496	Q14781
PDB IDs		2H0D 3GS2 3H8H 3IXS 3RPG 4R8P 4S3O	2D9U 3H91 5EPK
Enriched GO Terms of Interacting Partners?
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