PCGF6 and KDM5D

Number of citations of the paper that reports this interaction (PubMedID 17320162)
103

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		PCGF6	KDM5D
Description		polycomb group ring finger 6	lysine demethylase 5D
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Fibrillar Center Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-trimethyl-K4 Specific) Metal Ion Binding Androgen Receptor Binding Dioxygenase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Inactivation Of X Chromosome By Genetic Imprinting Negative Regulation Of G0 To G1 Transition	Chromatin Remodeling Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Oxidation-reduction Process Regulation Of Androgen Receptor Signaling Pathway
Pathways		Transcriptional Regulation by E2F6	HDMs demethylate histones
Drugs			Vitamin C
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Schizophrenia ( 25056061 29483656 23974872)
Interacting Genes		22 interacting genes: BMI1 CBX6 CBX7 CDK7 E2F6 EIF2B2 H3-4 KDM5D MAGEA1 MAGEC2 MAGEE2 MAGEL2 PEX10 PNMA1 RAD18 RNF2 SS18L1 TRIM14 UBE2D3 UBE2U USP2 USP21	2 interacting genes: H3-4 PCGF6
Entrez ID		84108	8284
HPRD ID		07427	02464
Ensembl ID		ENSG00000156374	ENSG00000012817
Uniprot IDs		Q9BYE7	A0A384MR42 Q9BY66
PDB IDs		2DJB	2E6R 2YQE
Enriched GO Terms of Interacting Partners?
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