PTBP1 and HNRNPL

Number of citations of the paper that reports this interaction (PubMedID 26344197)
117

Data Source:
BioGRID (biochemical)
HPRD (in vitro, two hybrid)

		PTBP1	HNRNPL
Description		polypyrimidine tract binding protein 1	heterogeneous nuclear ribonucleoprotein L
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytosol Membrane Ribonucleoprotein Granule Pronucleus Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Poly-pyrimidine Tract Binding Pre-mRNA Binding	RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Transcription Regulatory Region DNA Binding Pre-mRNA Intronic Binding MRNA CDS Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of Translation RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Protein Dephosphorylation Regulation Of RNA Splicing Regulation Of Cell Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade IRES-dependent Viral Translational Initiation	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Processing Regulation Of Translation Circadian Rhythm RNA Metabolic Process Cellular Response To Amino Acid Starvation Regulation Of RNA Splicing Positive Regulation Of Translation Negative Regulation Of MRNA Splicing, Via Spliceosome Response To Peptide Positive Regulation Of MRNA Binding
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
Drugs			Copper
Diseases
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Anti-saccade response ( 29064472) Logical memory (immediate recall) in mild cognitive impairment ( 29274321)
Interacting Genes		28 interacting genes: APBB1 APP CALCOCO2 CASP3 FUS H3-4 HIF1A HMGA1 HMGA2 HNRNPAB HNRNPL IL7R LINC00839 MARK4 NONO PCBP1 PCBP2 PCBP3 PRKACA QKI RAVER1 RAVER2 RBFOX2 RBM10 SFPQ SNRPA SRPK2 ZMYM2	16 interacting genes: APEX1 CSE1L CSNK2A1 FGFR3 H3-4 HMG20B HMGA1 HNRNPA2B1 HNRNPK IL7R ITCH NEDD4 PCBP2 PJA1 PTBP1 SUMO4
Entrez ID		5725	3191
HPRD ID		02823	04360
Ensembl ID		ENSG00000011304	ENSG00000104824
Uniprot IDs		P26599	P14866 Q6NTA2
PDB IDs		1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 2N3O 3ZZY 3ZZZ	3R27 3TO8
Enriched GO Terms of Interacting Partners?
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