PTBP1 and RBFOX2

Number of citations of the paper that reports this interaction (PubMedID 22365833)
132

Data Source:
BioGRID (two hybrid)

		PTBP1	RBFOX2
Description		polypyrimidine tract binding protein 1	RNA binding fox-1 homolog 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Binding MRNA Binding Protein Binding Poly-pyrimidine Tract Binding Pre-mRNA Binding	Transcription Corepressor Activity RNA Binding MRNA Binding Protein Binding Transcription Factor Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of Translation RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Protein Dephosphorylation Regulation Of RNA Splicing Regulation Of Cell Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade IRES-dependent Viral Translational Initiation	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Definitive Erythrocyte Differentiation RNA Metabolic Process Radial Glia Guided Migration Of Purkinje Cell Intracellular Estrogen Receptor Signaling Pathway Regulation Of Cell Proliferation Negative Regulation Of Transcription, DNA-templated Dendrite Morphogenesis Neuromuscular Process Controlling Balance
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	FGFR2 alternative splicing
Drugs
Diseases
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Reading disability or specific language impairment (pleiotropy) ( 25065397) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		28 interacting genes: APBB1 APP CALCOCO2 CASP3 FUS H3-4 HIF1A HMGA1 HMGA2 HNRNPAB HNRNPL IL7R LINC00839 MARK4 NONO PCBP1 PCBP2 PCBP3 PRKACA QKI RAVER1 RAVER2 RBFOX2 RBM10 SFPQ SNRPA SRPK2 ZMYM2	53 interacting genes: APH1A ATN1 ATXN1 ATXN1L BOLL BRD7 C1orf94 CAMK2B CHAF1A CLASP2 DAB1 DAZAP2 DDX5 DEDD2 DMRTB1 ELAVL1 ELAVL2 ESR1 ESR2 GLIS2 GTF2A1L HNRNPAB HNRNPF HNRNPH2 HNRNPK KHDRBS1 MAGED1 MAPK1IP1L MED7 NAF1 NR2E3 PCBP1 POLR3D PSMA3 PSMF1 PTBP1 QKI RBFOX1 RBM22 RBM23 RBM42 RBPMS RERE RHOXF2 RNF8 SF3A1 SMN1 SNRPC SPOP TOLLIP U2AF2 VAC14 ZNF137P
Entrez ID		5725	23543
HPRD ID		02823	15231
Ensembl ID		ENSG00000011304	ENSG00000100320
Uniprot IDs		P26599	O43251
PDB IDs		1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 2N3O 3ZZY 3ZZZ	2CQ3
Enriched GO Terms of Interacting Partners?
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