PTBP1 and HMGA2

Number of citations of the paper that reports this interaction (PubMedID 18850631)
11

Data Source:
BioGRID (pull down)

		PTBP1	HMGA2
Description		polypyrimidine tract binding protein 1	high mobility group AT-hook 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Membrane Extracellular Exosome	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding Poly-pyrimidine Tract Binding Pre-mRNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding AT DNA Binding Transcription Coregulator Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding Transcription Regulatory Region DNA Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome MRNA Processing Regulation Of Translation RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway RNA Metabolic Process Negative Regulation Of RNA Splicing Positive Regulation Of Protein Dephosphorylation Regulation Of RNA Splicing Regulation Of Cell Differentiation Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Muscle Cell Differentiation Positive Regulation Of Calcineurin-NFAT Signaling Cascade IRES-dependent Viral Translational Initiation	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of Transcription, DNA-templated Mitotic G2 DNA Damage Checkpoint Multicellular Organism Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Histone H2A-S139 Phosphorylation Senescence-associated Heterochromatin Focus Assembly Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cellular Response To X-ray Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug
Pathways		FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Adverse response to drug ( 30420678) Aortic root size ( 19584346) Axial length ( 24144296) Birth length ( 25281659) Birth weight ( 23202124 31043758 27680694) Brain structure ( 22504417) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Head circumference (infant) ( 22504419) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 22021425 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 17767157) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Late-onset Alzheimer's disease ( 27770636) Medication use (drugs used in diabetes) ( 31015401) Offspring birth weight ( 31043758) Permanent tooth development ( 21931568) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 25102180 30297969 20581827 28869590) Type 2 diabetes nephropathy ( 21150874) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		28 interacting genes: APBB1 APP CALCOCO2 CASP3 FUS H3-4 HIF1A HMGA1 HMGA2 HNRNPAB HNRNPL IL7R LINC00839 MARK4 NONO PCBP1 PCBP2 PCBP3 PRKACA QKI RAVER1 RAVER2 RBFOX2 RBM10 SFPQ SNRPA SRPK2 ZMYM2	21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53 XRCC6
Entrez ID		5725	8091
HPRD ID		02823	02827
Ensembl ID		ENSG00000011304	ENSG00000149948
Uniprot IDs		P26599	F5H2A4 F5H6H0 P52926 Q1M183
PDB IDs		1QM9 1SJQ 1SJR 2AD9 2ADB 2ADC 2EVZ 2N3O 3ZZY 3ZZZ
Enriched GO Terms of Interacting Partners?
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