RTN4 and WWP1

Number of citations of the paper that reports this interaction (PubMedID 19035836)
7

Data Source:
BioGRID (pull down, affinity chromatography technology)

		RTN4	WWP1
Description		reticulon 4	WW domain containing E3 ubiquitin protein ligase 1
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GO Annotations	Cellular Component	Cell Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Cell Junction Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell
Pathways		Axonal growth inhibition (RHOA activation)	Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Obesity (extreme) ( 19553259) Systolic blood pressure ( 30224653)	Estimated glomerular filtration rate ( 31152163)
Interacting Genes		42 interacting genes: BAIAP2 BCL2 BCL2L1 CERT1 CGREF1 CHMP6 CLN8 CNTNAP1 CRMP1 FXR2 GLP1R HLA-DPB1 IPP LAMA4 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	49 interacting genes: ARRDC2 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WBP1 WBP2 YWHAQ ZNF638
Entrez ID		57142	11059
HPRD ID		07259	03811
Ensembl ID		ENSG00000115310	ENSG00000123124
Uniprot IDs		Q9NQC3	Q9H0M0
PDB IDs		2G31 2JV5	1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y
Enriched GO Terms of Interacting Partners?
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