WWP1 and TGIF1

Number of citations of the paper that reports this interaction (PubMedID 18511908)
12

Data Source:
HPRD (in vivo)

		WWP1	TGIF1
Description		WW domain containing E3 ubiquitin protein ligase 1	TGFB induced factor homeobox 1
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Nuclear Chromatin Nucleoplasm
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Co-SMAD Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Response To Drug Cellular Response To Growth Factor Stimulus
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Drugs
Diseases			Holoprosencephaly (HPE)
GWAS		Estimated glomerular filtration rate ( 31152163)	Metabolite levels ( 23823483) Periodontitis (DPAL) ( 24024966) Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		49 interacting genes: ARRDC2 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WBP1 WBP2 YWHAQ ZNF638	21 interacting genes: A2M APP AR CTBP1 CTBP2 EEF1A1 HDAC1 HMGB1 IRF2BP1 JUN LRIF1 MAPK1 MAPK3 MDFI MED31 MOB3A PML SIN3A SMAD2 SMAD3 WWP1
Entrez ID		11059	7050
HPRD ID		03811	04023
Ensembl ID		ENSG00000123124	ENSG00000177426
Uniprot IDs		Q9H0M0	Q15583
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	2LK2 6FQP 6FQQ
Enriched GO Terms of Interacting Partners?
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