RTN4 and ZFYVE21

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RTN4	ZFYVE21
Description		reticulon 4	zinc finger FYVE-type containing 21
Image
GO Annotations	Cellular Component	Cell Nuclear Envelope Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Postsynaptic Density Cell Junction Integral Component Of Endoplasmic Reticulum Membrane Cell Projection Neuronal Cell Body Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Membrane	Endosome Focal Adhesion
	Molecular Function	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Cadherin Binding	Protein Binding Metal Ion Binding
	Biological Process	Blastocyst Formation Apoptotic Process Axonal Fasciculation Positive Regulation Of Epithelial Cell Migration Cerebral Cortex Radial Glia Guided Migration Negative Regulation Of Cell Growth Negative Regulation Of Axon Extension Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Toll-like Receptor 9 Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Axonogenesis Protein Stabilization Nuclear Pore Complex Assembly Positive Regulation Of Protein Kinase B Signaling Cardiac Epithelial To Mesenchymal Transition Protein Localization To Lysosome Endoplasmic Reticulum Tubular Network Organization Endoplasmic Reticulum Tubular Network Formation Cellular Sphingolipid Homeostasis Positive Regulation Of Protein Localization To Endoplasmic Reticulum Positive Regulation Of ERBB3 Signaling Pathway Endoplasmic Reticulum Tubular Network Membrane Organization Regulation Of Branching Morphogenesis Of A Nerve
Pathways		Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Obesity (extreme) ( 19553259) Systolic blood pressure ( 30224653)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 26426971) Schizophrenia ( 25056061 29483656)
Interacting Genes		42 interacting genes: BAIAP2 BCL2 BCL2L1 CERT1 CGREF1 CHMP6 CLN8 CNTNAP1 CRMP1 FXR2 GLP1R HLA-DPB1 IPP LAMA4 LMNA LRCH4 LRPAP1 MBP NAPA NR4A1 NRXN1 NSD1 PLEKHF2 POT1 PPP1R21 PRR13 RAB33A RPS27 RTN3 RTN4IP1 RTN4R SNX1 SNX15 SPG21 STON1 SYT16 TERF1 TUBA4A UQCRC1 UQCRC2 WWP1 ZFYVE21	23 interacting genes: AGTRAP ARL6IP1 CAPN2 FBXO7 KRT31 KRT38 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP5-9 MID2 MTUS2 NOTCH2NLA PDE4DIP PTK2 RABAC1 REEP6 RTN4 SIAH1 TRAF1 TRIM27 TUBB
Entrez ID		57142	79038
HPRD ID		07259	15733
Ensembl ID		ENSG00000115310	ENSG00000100711
Uniprot IDs		Q9NQC3	Q9BQ24
PDB IDs		2G31 2JV5	2RRF
Enriched GO Terms of Interacting Partners?
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