WWP1 and NFE2

Number of citations of the paper that reports this interaction (PubMedID 9753456)
20

Data Source:
HPRD (in vitro)

		WWP1	NFE2
Description		WW domain containing E3 ubiquitin protein ligase 1	nuclear factor, erythroid 2
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm PML Body Protein-DNA Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Protein N-terminus Binding WW Domain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Nucleosome Disassembly Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Blood Coagulation Hemostasis Blood Circulation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Chronotype ( 30696823) Mean platelet volume ( 22139419 24026423) Platelet count ( 29403010 27863252) Plateletcrit ( 27863252) Red cell distribution width ( 28957414) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		49 interacting genes: ARRDC2 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WBP1 WBP2 YWHAQ ZNF638	22 interacting genes: ATF4 BTRC CREBBP ELF5 HMGN1 ITCH KAT2B MAFF MAFG MAFK MAPK8 NEDD4 NFE2L2 NFE2L3 PEX14 PHYHIP PRIM1 SCAND1 SSX5 TXN WWP1 YAP1
Entrez ID		11059	4778
HPRD ID		03811	09030
Ensembl ID		ENSG00000123124	ENSG00000123405
Uniprot IDs		Q9H0M0	A8K3E0 Q16621
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	1LVX 2KZ5
Enriched GO Terms of Interacting Partners?
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