WWP1 and DAG1

Number of citations of the paper that reports this interaction (PubMedID 9169421)
41

Data Source:
HPRD (in vitro)

		WWP1	DAG1
Description		WW domain containing E3 ubiquitin protein ligase 1	dystroglycan 1
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Extracellular Region Basement Membrane Extracellular Space Cell Nucleoplasm Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Cytosol Cytoskeleton Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Integral Component Of Membrane Basolateral Plasma Membrane Lamellipodium Filopodium Node Of Ranvier Nuclear Periphery Sarcolemma Costamere Plasma Membrane Raft Postsynaptic Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Contractile Ring Glutamatergic Synapse GABA-ergic Synapse Postsynaptic Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Virus Receptor Activity Dystroglycan Binding Actin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Tubulin Binding Vinculin Binding SH2 Domain Binding Laminin-1 Binding Alpha-actinin Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	Positive Regulation Of Cell-matrix Adhesion Morphogenesis Of An Epithelial Sheet Membrane Protein Ectodomain Proteolysis Cytoskeletal Anchoring At Plasma Membrane Aging Regulation Of Gastrulation Regulation Of Epithelial To Mesenchymal Transition Response To Denervation Involved In Regulation Of Muscle Adaptation Calcium-dependent Cell-matrix Adhesion Regulation Of Embryonic Cell Shape Modulation By Virus Of Host Morphology Or Physiology Nerve Maturation Myelination In Peripheral Nervous System Extracellular Matrix Organization Negative Regulation Of Cell Migration Axon Regeneration Positive Regulation Of Myelination Microtubule Anchoring Skeletal Muscle Tissue Regeneration Negative Regulation Of MAPK Cascade Response To Peptide Hormone Positive Regulation Of Protein Kinase Activity Viral Entry Into Host Cell Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Synapse Organization Negative Regulation Of Protein Kinase B Signaling Angiogenesis Involved In Wound Healing Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Cellular Response To Mechanical Stimulus Cellular Response To Cholesterol Commissural Neuron Axon Guidance Basement Membrane Organization Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Retrograde Trans-synaptic Signaling By Trans-synaptic Protein Complex Positive Regulation Of Basement Membrane Assembly Involved In Embryonic Body Morphogenesis
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Non-integrin membrane-ECM interactions ECM proteoglycans ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation Regulation of expression of SLITs and ROBOs EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases			Limb-girdle muscular dystrophy (LGMD)
GWAS		Estimated glomerular filtration rate ( 31152163)	Blood protein levels ( 29875488 28240269) Body mass index ( 26426971) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Mood instability ( 31168069) Pediatric autoimmune diseases ( 26301688) Regular attendance at a religious group ( 29970889) Resting heart rate ( 27798624) Sleep duration (short sleep) ( 30846698) Ulcerative colitis ( 28067908)
Interacting Genes		49 interacting genes: ARRDC2 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WBP1 WBP2 YWHAQ ZNF638	25 interacting genes: AGR2 AGR3 AGRN BGN CAV1 CAV3 DMD DRP2 FYN GRB2 ITGB1 LAMA1 LAMA2 LAMA5 MAGI1 MAP2 NCK1 RAPSN SHC1 SRC TLN1 TUBA1A UTRN WWP1 WWP2
Entrez ID		11059	1605
HPRD ID		03811	00546
Ensembl ID		ENSG00000123124	ENSG00000173402
Uniprot IDs		Q9H0M0	A0A024R2W4 Q14118
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	1EG4 2MK7 5GGP 5LLK 6JJY
Enriched GO Terms of Interacting Partners?
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