WWP1 and ZNF638

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WWP1	ZNF638
Description		WW domain containing E3 ubiquitin protein ligase 1	zinc finger protein 638
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm Cytosol Plasma Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Protein Ligase Activity	Double-stranded DNA Binding RNA Binding Zinc Ion Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Signal Transduction Central Nervous System Development Protein Ubiquitination Ion Transmembrane Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Viral Entry Into Host Cell	RNA Splicing
Pathways		Downregulation of ERBB4 signaling Stimuli-sensing channels Regulation of RUNX2 expression and activity Antigen processing: Ubiquitination & Proteasome degradation	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163)	Cognitive ability ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Heel bone mineral density ( 30598549 28869591) Height ( 25282103 25429064 31562340 23456168) Hip circumference adjusted for BMI ( 28552196) Intelligence ( 28530673) Pulse pressure ( 27841878 30578418) QRS interval (sulfonylurea treatment interaction) ( 27958378) Reaction time ( 29844566) Testicular germ cell tumor ( 28604728)
Interacting Genes		49 interacting genes: ARRDC2 ASH2L ATN1 CLCN5 CPSF6 DAG1 DAZAP2 DIDO1 EWSR1 FAM189A2 FBXL18 HSPB1 IKBKG IL2RG IL6R KLF2 KLF5 LAPTM5 LATS1 LNX1 LZTR1 MACROH2A2 NFE2 NOTCH1 PCBD1 PHF20L1 PRKAA2 RASA1 RNF11 RTN4 RUNX1 SCNN1A SFTPC SMAD3 SMAD5 STAT6 TFAP2A TGIF1 TP53BP2 TRAF4 UBC UBE2D1 UBE2D2 UBE2D3 UBE2L3 WBP1 WBP2 YWHAQ ZNF638	13 interacting genes: CALCOCO2 CCDC85B EFEMP2 FHL2 HOOK2 KIFBP KRT15 KRT19 KRTAP4-12 NELFCD PLSCR1 SPP1 WWP1
Entrez ID		11059	27332
HPRD ID		03811	11736
Ensembl ID		ENSG00000123124	ENSG00000075292
Uniprot IDs		Q9H0M0	A8K583 Q14966
PDB IDs		1ND7 2OP7 5HPS 5HPT 6J1X 6J1Y	6SXW
Enriched GO Terms of Interacting Partners?
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