PRKAR2A and GABARAPL2

		PRKAR2A	GABARAPL2
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	GABA type A receptor associated protein like 2
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GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Golgi Membrane Autophagosome Membrane Intracellular Cytoplasm Autophagosome Golgi Apparatus Cytosol Cytoplasmic Vesicle
	Molecular Function	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	SNARE Binding Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding
	Biological Process	Renal Water Homeostasis Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity	Autophagosome Assembly Autophagy Of Mitochondrion Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Macroautophagy Positive Regulation Of ATPase Activity Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production	Macroautophagy TBC/RABGAPs
Drugs		GEM-231
Diseases
GWAS		Blood protein levels ( 28240269) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)
Interacting Genes		41 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR GABARAPL2 HYAL1 MAP2 MSN MYCBPAP NBEA P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1	66 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 BCL2L13 CALCOCO1 CALCOCO2 CLN8 CUL3 EGFR FUNDC1 GIMAP6 GOSR1 GPR37 KASH5 KBTBD6 KBTBD7 KIAA1958 KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 MAP1LC3B MCPH1 MEFV MLX NBR1 NEDD4 NSF OPTN OSBPL7 PRKAR2A PTPRA RAP1A RAP2A RB1CC1 RCN2 RPS2 SGTA SIK2 SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TNIP1 TP53INP1 TP53INP2 TRIM21 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ
Entrez ID		5576	11345
HPRD ID		01484	16246
Ensembl ID		ENSG00000114302	ENSG00000034713
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A8KAH7 P13861	P60520
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY	4CO7
Enriched GO Terms of Interacting Partners?
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