GABARAPL2 and PRKAR2A

		GABARAPL2	PRKAR2A
Description		GABA type A receptor associated protein like 2	protein kinase cAMP-dependent type II regulatory subunit alpha
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GO Annotations	Cellular Component	Golgi Membrane Autophagosome Membrane Intracellular Cytoplasm Autophagosome Golgi Apparatus Cytosol Cytoplasmic Vesicle	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base
	Molecular Function	SNARE Binding Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding GABA Receptor Binding ATPase Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Autophagosome Assembly Autophagy Of Mitochondrion Intra-Golgi Vesicle-mediated Transport Autophagy Cellular Response To Nitrogen Starvation Protein Transport Macroautophagy Positive Regulation Of ATPase Activity Autophagosome Maturation Negative Regulation Of Proteasomal Protein Catabolic Process	Renal Water Homeostasis Blood Coagulation CGMP-mediated Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Macroautophagy TBC/RABGAPs	PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			GEM-231
Diseases
GWAS		Blood protein levels ( 30072576) Pancreatic cancer ( 25086665)	Blood protein levels ( 28240269) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Heel bone mineral density ( 30598549) Height ( 31562340) Inflammatory bowel disease ( 28067908) Morning person ( 30696823) Resting heart rate ( 27798624) Ulcerative colitis ( 28067908)
Interacting Genes		66 interacting genes: AAMP AGTRAP AHNAK2 AMBRA1 ANK2 APP ARFGAP1 ATG13 ATG3 ATG4A ATG4B ATG4D ATG7 BCL2L13 CALCOCO1 CALCOCO2 CLN8 CUL3 EGFR FUNDC1 GIMAP6 GOSR1 GPR37 KASH5 KBTBD6 KBTBD7 KIAA1958 KLHL5 KRTAP10-7 KRTAP10-9 LRSAM1 MAP1LC3B MCPH1 MEFV MLX NBR1 NEDD4 NSF OPTN OSBPL7 PRKAR2A PTPRA RAP1A RAP2A RB1CC1 RCN2 RPS2 SGTA SIK2 SQSTM1 TAX1BP1 TBC1D25 TBC1D5 TBC1D9 TBC1D9B TNIP1 TP53INP1 TP53INP2 TRIM21 TSR2 UBA5 ULK1 ULK2 VDR WDFY3 YWHAZ	41 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CFTR EZR GABARAPL2 HYAL1 MAP2 MSN MYCBPAP NBEA P4HA2 PJA2 PPP1CB PRKX RAB32 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 XCR1
Entrez ID		11345	5576
HPRD ID		16246	01484
Ensembl ID		ENSG00000034713	ENSG00000114302
Uniprot IDs		P60520	A0A024R2W3 A0A0S2Z472 A8KAH7 P13861
PDB IDs		4CO7	2IZX 2KYG 4ZP3 5H78 5XBY
Enriched GO Terms of Interacting Partners?
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