POU2F1 and POU2AF1

Number of citations of the paper that reports this interaction (PubMedID 9418884)
35

Data Source:
BioGRID (x-ray crystallography, two hybrid, pull down)
HPRD (in vitro, in vivo)

		POU2F1	POU2AF1
Description		POU class 2 homeobox 1	POU class 2 homeobox associating factor 1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex	RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Cytokine-mediated Signaling Pathway Cell Differentiation SnRNA Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Transcription By RNA Polymerase II Humoral Immune Response Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Asthma ( 31619474) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)	Celiac disease ( 22057235) Corneal structure ( 23291589) Diverticular disease ( 30177863) Hodgkin's lymphoma ( 30194254) Low urine pH ( 30476138) Multiple sclerosis ( 31604244) Primary biliary cholangitis ( 23000144 28062665) Serum urea levels ( 30808845) Urine pH measurement ( 30476138)
Interacting Genes		49 interacting genes: APP AR BARD1 BRCA1 CEBPE CREB1 ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 VDR XRCC6	19 interacting genes: GATA2 GCC2 GTF2H1 GTF2I MSX2 NAB1 NOTCH1 PAX8 POU2F1 POU2F2 PTPN11 RHOXF2 SIAH1 SIAH2 SLC22A1 SLC22A2 SMAD2 SUB1 SYK
Entrez ID		5451	5450
HPRD ID		01250	03126
Ensembl ID		ENSG00000143190	ENSG00000110777
Uniprot IDs		A0A024R8Y2 P14859	Q16633
PDB IDs		1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU	1CQT
Enriched GO Terms of Interacting Partners?
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