POU2F1 and HCFC1

Number of citations of the paper that reports this interaction (PubMedID 8454622)
52

Data Source:
BioGRID (pull down, biochemical, affinity chromatography technology)

		POU2F1	HCFC1
Description		POU class 2 homeobox 1	host cell factor C1
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex	Histone Acetyltransferase Complex Nucleus Nucleoplasm Ada2/Gcn5/Ada3 Transcription Activator Complex Cytoplasm Membrane Axon Dendrite Protein-containing Complex Neuronal Cell Body Set1C/COMPASS Complex SAGA-type Complex MLL1 Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Transcription Factor Binding Protein Binding, Bridging Activating Transcription Factor Binding Identical Protein Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Cadherin Binding Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Cytokine-mediated Signaling Pathway Cell Differentiation SnRNA Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Hatching Chromatin Remodeling Regulation Of Transcription, DNA-templated Mitochondrion Organization Cell Cycle Positive Regulation Of Gene Expression Protein Deubiquitination Release From Viral Latency Regulation Of Protein Complex Assembly Histone H4 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Protein Stabilization Cellular Response To Organic Cyclic Compound
Pathways		Interleukin-4 and Interleukin-13 signaling RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter Estrogen-dependent gene expression	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones UCH proteinases
Drugs
Diseases
GWAS		Asthma ( 31619474) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Diastolic blood pressure ( 30224653) Liver enzyme levels ( 18940312) Pre-treatment viral load in HIV-1 infection ( 31219150)	Celiac disease ( 22057235) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Systemic lupus erythematosus ( 26502338)
Interacting Genes		49 interacting genes: APP AR BARD1 BRCA1 CEBPE CREB1 ESR1 FDXR HCFC1 HMGA1 HMGB2 HNF1A HOXB13 HOXC9 IRF9 LIFR MNAT1 MSX1 NCOR2 NFYA NPAT NR3C1 PARP1 PBX1 PGR PKNOX1 PLK3 POGZ POU2AF1 PRKACA PRKDC RARA RELA RXRA SNAPC4 SOX2 SP1 SP4 STAT5A STAT5B TBP THRA TLE4 TLE5 TLX2 TNF TXNRD1 VDR XRCC6	32 interacting genes: ASF1B CLP1 CREB3 CREBZF E2F1 E2F3 E2F4 EGR2 FOXK2 GABPA GABPB1 HCFC1R1 HSPA1A JUN KMT2A MED25 NFE2L1 OGT PDCD2 POU2F1 PPARGC1A PPARGC1B PPP1CC PSIP1 SETD7 SIN3A SP1 TAF9 THAP11 THAP7 YY1 ZBTB17
Entrez ID		5451	3054
HPRD ID		01250	02061
Ensembl ID		ENSG00000143190	ENSG00000172534
Uniprot IDs		A0A024R8Y2 P14859	A6NEM2 P51610
PDB IDs		1CQT 1E3O 1GT0 1HF0 1O4X 1OCT 1POG 1POU	4GO6 4N39 4N3A 4N3B 4N3C 5LWV 6MA1 6MA2 6MA3 6MA4 6MA5
Enriched GO Terms of Interacting Partners?
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