NDN and IRS4

Number of citations of the paper that reports this interaction (PubMedID 28973533)
2

Data Source:
BioGRID (two hybrid)

		NDN	IRS4
Description		necdin, MAGE family member	insulin receptor substrate 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell Projection Perikaryon	Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Gamma-tubulin Binding	SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Neuron Migration Respiratory System Process Nervous System Development Axonal Fasciculation Central Nervous System Development Negative Regulation Of Cell Proliferation Glial Cell Migration Post-embryonic Development Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Regulation Of Growth Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Axon Extension Multicellular Organismal Homeostasis Genetic Imprinting	Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction
Pathways		Interleukin-4 and Interleukin-13 signaling	IRS-related events triggered by IGF1R
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Depressive symptoms (SSRI exposure interaction) ( 25649181) Plasma anti-thyroid peroxidase levels ( 29678681) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MPP6 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B	21 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MTNR1A MTNR1B NDN NISCH PIK3CA PIK3R1 PRKCZ PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG
Entrez ID		4692	8471
HPRD ID		03667	04620
Ensembl ID		ENSG00000182636	ENSG00000133124
Uniprot IDs		Q99608 X5D982	O14654
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?