SH2D1A and LHX4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		SH2D1A	LHX4
Description		SH2 domain containing 1A	LIM homeobox 4
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nuclear Chromatin Nucleus
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Placenta Development Motor Neuron Axon Guidance Animal Organ Morphogenesis Medial Motor Column Neuron Differentiation Neuron Differentiation Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Regulation of expression of SLITs and ROBOs
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS
Interacting Genes		26 interacting genes: ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB3 FYB1 FYN GRB2 LCK LETMD1 LHX4 LY9 MAPK11 MAPK14 NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	22 interacting genes: ADAMTSL4 AXIN1 CHCHD2 FDX2 GOLGA2 IFT172 IKZF1 KRT38 KRT40 LDB2 LONRF1 NRF1 ORC6 SH2D1A SNRNP25 SSX1 TCAP TCF4 TP53BP2 TXNDC5 UBQLN1 USP2
Entrez ID		4068	89884
HPRD ID		02390	03686
Ensembl ID		ENSG00000183918	ENSG00000121454
Uniprot IDs		O60880	A0A0S2Z5S4 Q969G2
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	5HOD
Enriched GO Terms of Interacting Partners?
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