LASP1 and ACTC1

Number of citations of the paper that reports this interaction (PubMedID 9848085)
27

Data Source:
HPRD (in vivo, in vitro)

		LASP1	ACTC1
Description		LIM and SH3 protein 1	actin alpha cardiac muscle 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion Cortical Actin Cytoskeleton	Extracellular Space Cytoplasm Cytosol Actin Filament Focal Adhesion Actin Cytoskeleton Membrane Sarcomere Lamellipodium Filopodium I Band Actomyosin, Actin Portion Cell Body Extracellular Exosome Blood Microparticle Glutamatergic Synapse
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding	ATP Binding ATPase Activity Myosin Binding
	Biological Process	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport	Actin Filament Organization Positive Regulation Of Gene Expression Actin Filament-based Movement Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Actomyosin Structure Organization Actin-myosin Filament Sliding Negative Regulation Of Apoptotic Process Response To Ethanol Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Heart Contraction Cardiac Muscle Contraction Mesenchyme Migration
Pathways			Striated Muscle Contraction
Drugs
Diseases			Hypertrophic cardiomyopathy (HCM) Atrial septal defect Dilated cardiomyopathy (DCM)
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)	Axial length ( 24144296) Refractive error ( 20835239)
Interacting Genes		40 interacting genes: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 COPS5 CRK DAZAP2 DNMT1 EHMT2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 RBPMS REL RHOXF2 SEPTIN3 SPRY2 STAT3 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 UHRF1 ZBTB9 ZC2HC1A ZYX	39 interacting genes: ABLIM3 ABRA ACTB ACTN4 ACTR2 AFAP1 ANG BCL11A CAPN1 CFL1 DMD DMTN DYNLL1 EZR FBXO7 FSCN1 GAPDH GC HSPB1 HSPB2 KAT14 KLHL17 KLHL2 KPTN LASP1 MIB2 MPC1 MYLK PLEC PRKCE SCIN SLC4A1 SYNE1 SYNE2 TNNI3K TWF1 UBC WAS WIPF1
Entrez ID		3927	70
HPRD ID		04229	00015
Ensembl ID		ENSG00000002834	ENSG00000159251
Uniprot IDs		A0A024R1S8 B4DIC4 Q14847	B3KPP5 P68032
PDB IDs		3I35
Enriched GO Terms of Interacting Partners?
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