KIT and GRAP2

Number of citations of the paper that reports this interaction (PubMedID 9872323)
33

Data Source:
HPRD (in vitro)

		KIT	GRAP2
Description		KIT proto-oncogene, receptor tyrosine kinase	GRB2 related adaptor protein 2
Image
GO Annotations	Cellular Component	Fibrillar Center Acrosomal Vesicle Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Mast Cell Granule Receptor Complex	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Protease Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Stem Cell Factor Receptor Activity Protein Binding ATP Binding Growth Factor Binding Cytokine Binding SH2 Domain Binding Protein Homodimerization Activity Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Ovarian Follicle Development Hematopoietic Progenitor Cell Differentiation Myeloid Progenitor Cell Differentiation Lymphoid Progenitor Cell Differentiation Immature B Cell Differentiation Dendritic Cell Cytokine Production Mast Cell Chemotaxis Regulation Of Transcription By RNA Polymerase II Glycosphingolipid Metabolic Process Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Spermatogenesis Spermatid Development Positive Regulation Of Cell Proliferation Germ Cell Migration Regulation Of Cell Shape Visual Learning Male Gonad Development Positive Regulation Of Gene Expression Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Stem Cell Population Maintenance Lamellipodium Assembly Hemopoiesis B Cell Differentiation T Cell Differentiation Erythrocyte Differentiation Melanocyte Differentiation Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Actin Cytoskeleton Reorganization Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Somatic Stem Cell Population Maintenance Embryonic Hemopoiesis Ectopic Germ Cell Programmed Cell Death Hematopoietic Stem Cell Migration Megakaryocyte Development Fc Receptor Signaling Pathway Kit Signaling Pathway Erythropoietin-mediated Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Programmed Cell Death Mast Cell Degranulation Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Pigmentation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Tongue Development Positive Regulation Of Notch Signaling Pathway Positive Regulation Of JAK-STAT Cascade Response To Cadmium Ion Protein Autophosphorylation Somatic Stem Cell Division Positive Regulation Of Long-term Neuronal Synaptic Plasticity Digestive Tract Development Stem Cell Differentiation Epithelial Cell Proliferation Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Cell Chemotaxis Mast Cell Differentiation Mast Cell Proliferation Cellular Response To Thyroid Hormone Stimulus Melanocyte Migration Melanocyte Adhesion Positive Regulation Of Pyloric Antrum Smooth Muscle Contraction Regulation Of Bile Acid Metabolic Process Positive Regulation Of Colon Smooth Muscle Contraction Positive Regulation Of Small Intestine Smooth Muscle Contraction Positive Regulation Of Vascular Smooth Muscle Cell Differentiation	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways		PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Regulation of KIT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors	Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs		Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Nilotinib XL820 OSI-930 ABT-869 Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Amuvatinib
Diseases		Piebaldism Acute myeloid leukemia (AML)
GWAS		Anorexia nervosa or obsessive-compulsive disorder ( 30087453) Bipolar disorder ( 19416921) Breastfeeding duration ( 25475840) Cadmium levels ( 26025379) Hematocrit ( 29403010 28017375) Hemoglobin ( 29403010) Hemoglobin levels ( 28017375) Mean corpuscular hemoglobin ( 29403010 28453575 28017375) Mean corpuscular volume ( 29403010 28453575 20139978 28017375 19862010) Platelet count ( 29403010) Red blood cell count ( 29403010 28453575 28017375) Red blood cell traits ( 23222517) Schizophrenia ( 26198764) Serum VEGFR2 concentration ( 25411163) Systemic lupus erythematosus ( 29494758)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		60 interacting genes: ABL1 BTK CBL CBLB CD81 CD9 CISH CLTC CRK CRKL CSF1R CSF2RA CSF2RB DOK1 EPOR FYN GRAP GRAP2 GRB10 GRB2 GRB7 HCK IL7R ILKAP INPP5D JAK2 JAK3 KITLG LCK LYN MATK MPDZ PIK3CG PIK3R1 PIK3R2 PLCE1 PLCG1 PRKCA PRKCB PTPN11 PTPN20 PTPN6 PTPRO PTPRU RASA1 SH2B2 SH2B3 SOCS1 SOCS5 SOCS6 SPRED1 SPRED2 SRC STAP1 STAT1 STAT5A STAT5B STYX TEC YES1	66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526
Entrez ID		3815	9402
HPRD ID		01287	05156
Ensembl ID		ENSG00000157404	ENSG00000100351
Uniprot IDs		A0A0U2N547 P10721	B7Z8E3 O75791 Q6FI14
PDB IDs		1PKG 1QZJ 1QZK 1R01 1T45 1T46 2E9W 2EC8 2IUH 2VIF 3G0E 3G0F 4HVS 4K94 4K9E 4PGZ 4U0I 6GQJ 6GQK 6GQL 6GQM 6HH1 6ITT 6ITV 6KLA 6MOB	5GJH
Enriched GO Terms of Interacting Partners?
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