LCE3C and EFEMP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LCE3C	EFEMP2
Description		late cornified envelope 3C	EGF containing fibulin extracellular matrix protein 2
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Region Basement Membrane Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Binding	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Keratinization Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Elastic Fiber Assembly
Pathways		Formation of the cornified envelope	Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases			Cutis laxa, including: Autosomal dominant cutis laxa (ADCL); Autosomal recessive cutis laxa I (ARCL1); Autosomal recessive cutis laxa II (ARCL2); X-linked recessive cutis laxa (XRCL); Wrinkly skin syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Acne (severe) ( 24927181) Birth weight ( 31043758)
Interacting Genes		16 interacting genes: ADAMTSL4 EFEMP2 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-9 KRTAP9-4 NOTCH2NLA PCSK5 PLSCR1 RGS17 SPRY2	52 interacting genes: AMMECR1 APEX2 AQP1 ATN1 ATXN1 ATXN7 BAG6 C5orf24 CACNA1A CATSPER1 CCDC33 CCND3 CCNK COL8A1 CREB5 DGCR6 FAM107A FAM124B FAM74A4 GFI1B GLRX3 HDAC4 HHEX HOXA1 IL16 LCE2D LCE3C LINGO1 MEOX2 NEDD4L NOS3 NUFIP2 PIDD1 PLSCR1 PLSCR4 PRPF31 PTGER3 RBPMS RERE RHOXF2 RHPN1 RIBC2 SGTA SGTB STK16 TCAF1 TP53 UBQLN1 UBQLN4 ZNF263 ZNF426 ZNF638
Entrez ID		353144	30008
HPRD ID		17262	05221
Ensembl ID		ENSG00000244057	ENSG00000172638
Uniprot IDs		Q5T5A8	A0A024R5G1 O95967 Q9H3D5
PDB IDs			2KL7
Enriched GO Terms of Interacting Partners?
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