LCE3C and PCSK5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LCE3C	PCSK5
Description		late cornified envelope 3C	proprotein convertase subtilisin/kexin type 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Extracellular Region Extracellular Space Golgi Apparatus Golgi Lumen Trans-Golgi Network Membrane Secretory Granule Integral Component Of Golgi Membrane
	Molecular Function	Protein Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Peptide Binding
	Biological Process	Keratinization Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Kidney Development Renin Secretion Into Blood Stream Cardiac Septum Development Signal Peptide Processing Cell-cell Signaling Determination Of Left/right Symmetry Heart Development Embryo Implantation Anterior/posterior Pattern Specification Protein Processing Peptide Hormone Processing Viral Life Cycle Respiratory Tube Development Nerve Growth Factor Processing Limb Morphogenesis Cytokine Biosynthetic Process Peptide Biosynthetic Process Embryonic Digestive Tract Development Embryonic Skeletal System Development Regulation Of Lipoprotein Lipase Activity Coronary Vasculature Development
Pathways		Formation of the cornified envelope	NGF processing Assembly of active LPL and LIPC lipase complexes
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Alzheimer's disease progression score ( 29860282) Amyotrophic lateral sclerosis (age of onset) ( 22959728) Ankylosing spondylitis ( 30946743) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) Glucocorticoid-induced osteonecrosis ( 26265699) Glucose homeostasis traits ( 25524916) Height ( 28552196 20881960 25282103 23563607 31562340) Inflammatory bowel disease ( 27569725) Intraocular pressure ( 29785010 31959993 30054594) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Lead levels ( 26025379) Male fertility ( 22633400) Metabolite levels (5-HIAA) ( 23319000) Pursuit maintenance gain ( 29064472) Response to fenofibrate (adiponectin levels) ( 23149075) Systemic sclerosis ( 30247649) Takayasu arteritis ( 25604533) Total ventricular volume (Alzheimer's disease interaction) ( 21116278) Vascular brain injury ( 25188341) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)
Interacting Genes		16 interacting genes: ADAMTSL4 EFEMP2 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP3-3 KRTAP4-2 KRTAP5-9 KRTAP9-4 NOTCH2NLA PCSK5 PLSCR1 RGS17 SPRY2	19 interacting genes: AMH APPBP2 ATN1 CACNA1A GLRX3 ITGA6 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP4-12 KRTAP5-9 LCE3C MEOX2 NOTCH2NLA NUFIP2 PMCH PTPRM REN STK16
Entrez ID		353144	5125
HPRD ID		17262	08985
Ensembl ID		ENSG00000244057	ENSG00000099139
Uniprot IDs		Q5T5A8	Q92824
PDB IDs
Enriched GO Terms of Interacting Partners?
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