HUS1 and SIRT6

Number of citations of the paper that reports this interaction (PubMedID 26063178)
8

Data Source:
BioGRID (pull down)

		HUS1	SIRT6
Description		HUS1 checkpoint clamp component	sirtuin 6
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Cytoplasm
	Molecular Function	Protein Binding	Chromatin Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity NAD-dependent Protein Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Replication DNA Repair Nucleotide-excision Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Response To UV Embryo Development Ending In Birth Or Egg Hatching Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint Cellular Response To Ionizing Radiation Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis Base-excision Repair Protein ADP-ribosylation Protein Deacetylation Negative Regulation Of Cell Proliferation Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Destabilization Response To Nutrient Levels Positive Regulation Of Chromatin Silencing At Telomere Positive Regulation Of Telomere Maintenance Glucose Homeostasis Negative Regulation Of Glycolytic Process Negative Regulation Of Glucose Import Positive Regulation Of Fibroblast Proliferation Histone H3-K9 Modification Histone H3 Deacetylation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Telomeric Heterochromatin Assembly Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Histone H3-K9 Deacetylation Positive Regulation Of Stem Cell Proliferation
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends
Drugs
Diseases
GWAS		Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)
Interacting Genes		23 interacting genes: CD200 DNAJC7 FEN1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 YWHAQ	17 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 ELF5 FAF1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A USP10 VIM
Entrez ID		3364	51548
HPRD ID		04787	12093
Ensembl ID		ENSG00000136273	ENSG00000077463
Uniprot IDs		A4D2F2 O60921	B4DDV3 M0QXA0 M0R1N9 Q8N6T7
PDB IDs		3A1J 3G65 3GGR	3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY
Enriched GO Terms of Interacting Partners?
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