HUS1 and RAD17

Number of citations of the paper that reports this interaction (PubMedID 10884395)
30

Data Source:
HPRD (in vivo)

		HUS1	RAD17
Description		HUS1 checkpoint clamp component	RAD17 checkpoint clamp loader component
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Rad17 RFC-like Complex
	Molecular Function	Protein Binding	Chromatin Binding Protein Binding ATP Binding
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Replication DNA Repair Nucleotide-excision Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Response To UV Embryo Development Ending In Birth Or Egg Hatching Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint Cellular Response To Ionizing Radiation Regulation Of Signal Transduction By P53 Class Mediator	DNA Replication Checkpoint DNA Damage Checkpoint DNA Replication DNA Repair Cellular Response To DNA Damage Stimulus Mitotic Cell Cycle Checkpoint Negative Regulation Of DNA Replication Mitotic DNA Replication Checkpoint Regulation Of Phosphorylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)	Blood urea nitrogen levels ( 31152163)
Interacting Genes		23 interacting genes: CD200 DNAJC7 FEN1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 YWHAQ	16 interacting genes: ATM ATR F2RL1 HUS1 MCM7 POLE PRKDC PRMT6 RAD1 RAD9A RAD9B RFC2 RFC3 RFC4 SNU13 USP20
Entrez ID		3364	5884
HPRD ID		04787	09124
Ensembl ID		ENSG00000136273	ENSG00000152942
Uniprot IDs		A4D2F2 O60921	O75943
PDB IDs		3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?
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