HUS1 and CD200

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		HUS1	CD200
Description		HUS1 checkpoint clamp component	CD200 molecule
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Axon Neuron Projection Neuronal Cell Body Cell Body
	Molecular Function	Protein Binding	Protein Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion Glycosylated Region Protein Binding
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Replication DNA Repair Nucleotide-excision Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Negative Regulation Of DNA Replication Response To UV Embryo Development Ending In Birth Or Egg Hatching Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint Cellular Response To Ionizing Radiation Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell Proliferation Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of CREB Transcription Factor Activity Heterotypic Cell-cell Adhesion Negative Regulation Of Macrophage Activation Regulation Of Immune Response Positive Regulation Of Transforming Growth Factor Beta Production Cell-cell Adhesion Positive Regulation Of Arginase Activity Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Neuron Death Negative Regulation Of Matrix Metallopeptidase Secretion Negative Regulation Of Macrophage Migration Negative Regulation Of T Cell Migration
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)	Blood protein levels ( 30072576) Cognitive decline rate in late mild cognitive impairment ( 26252872) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		23 interacting genes: CD200 DNAJC7 FEN1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SIRT6 TDG TOPBP1 YWHAQ	3 interacting genes: CD200R1 HCRTR2 HUS1
Entrez ID		3364	4345
HPRD ID		04787	01124
Ensembl ID		ENSG00000136273	ENSG00000091972
Uniprot IDs		A4D2F2 O60921	B4DDZ6 F8W7G1 P41217
PDB IDs		3A1J 3G65 3GGR
Enriched GO Terms of Interacting Partners?
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