CREB5 and RGS20

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CREB5	RGS20
Description		cAMP responsive element binding protein 5	regulator of G protein signaling 20
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Extracellular Exosome	Nucleus Cytoplasm Trans-Golgi Network Plasma Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Transcription, DNA-templated	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity
Pathways			G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS		Adolescent idiopathic scoliosis ( 31417091) Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Airflow obstruction ( 22837378) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Amyotrophic lateral sclerosis in C9orf72 mutation negative individuals ( 22959728) Anxiety in major depressive disorder ( 24047446) Asthma (childhood onset) ( 31036433) Atrial fibrillation ( 30061737 29892015) Attention deficit hyperactivity disorder ( 18839057) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Cleft lip with or without cleft palate x maternal periconceptional vitamin use interaction (parent of origin effect) ( 31372216) Crohn's disease ( 23128233) Diabetic retinopathy ( 21441570) Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189) Eosinophil percentage of granulocytes ( 27863252) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Hand grip strength ( 29691431) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Lymphocyte percentage of white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 29403010 27863252) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Pre-treatment viral load in HIV-1 infection ( 31219150) Pulse pressure ( 27841878 30578418) Serum thyroid-stimulating hormone levels ( 25436638) Smoking behaviour (cigarettes smoked per day) ( 31217584) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White blood cell count ( 29403010 27863252) White blood cell count (basophil) ( 27863252)	Cerebrospinal fluid beta-site APP cleaving enzyme levels ( 29751835) Serum uric acid levels ( 29559957) Urinary albumin-to-creatinine ratio ( 26631737)
Interacting Genes		40 interacting genes: ADAMTSL4 ATF2 COL8A1 EFEMP2 FOS FOSL1 FOSL2 JUN KIFC3 KRT15 KRT40 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LGALS13 MDFI MGAT5B MTUS2 NOTCH2NLA RBPMS RGS20 RIMBP3 SPOP SPRY1 SPRY2 TRAF2 TRIM23 TRIP6 TSGA10	34 interacting genes: ABHD17A ADRB2 AQP1 CATSPER1 CRCT1 CREB5 FASLG GLRX3 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 HSPD1 INS KIF1A KLHL38 KRTAP4-2 KRTAP5-6 KRTAP5-9 LCE1B LCE2A LCE2D LCE3E LCE4A MAPKBP1 NECTIN3 OSTM1 OTX1 PTGER3 PTPMT1 STMN2 TBC1D16
Entrez ID		9586	8601
HPRD ID		09896	06225
Ensembl ID		ENSG00000146592	ENSG00000147509
Uniprot IDs		Q02930	B3KSW4 H9NIM5 O76081
PDB IDs
Enriched GO Terms of Interacting Partners?
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