MT2A and LAMTOR5

Number of citations of the paper that reports this interaction (PubMedID 23241634)
1

Data Source:
BioGRID (two hybrid)

		MT2A	LAMTOR5
Description		metallothionein 2A	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
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GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Lysosome Lysosomal Membrane Cytosol Ragulator Complex
	Molecular Function	Protein Binding Drug Binding Zinc Ion Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Molecular Adaptor Activity
	Biological Process	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Cell Cycle Arrest Regulation Of Cell Size Response To Virus Positive Regulation Of Gene Expression Regulation Of Macroautophagy Viral Genome Replication Positive Regulation Of TOR Signaling Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Localization To Lysosome Cellular Response To Amino Acid Stimulus Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of TORC1 Signaling Positive Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	Macroautophagy mTOR signalling mTORC1-mediated signalling Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1
Drugs		Zinc
Diseases
GWAS
Interacting Genes		20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25	32 interacting genes: ALB ASGR1 BHMT C9 CD74 CEP126 CEP70 CFB CLCC1 DBI EEF1A1 GAPDH GIT1 GPRASP1 LAMTOR4 LRIF1 MAF1 MCPH1 MEOX2 MT2A NCOA6 PDK1 RABIF RBP4 SERPINA1 TAF9 TGFB1 TOP2B TP53 UTP14A YTHDC1 ZBTB16
Entrez ID		4502	10542
HPRD ID		08863	09773
Ensembl ID		ENSG00000125148	ENSG00000134248
Uniprot IDs		P02795	A0A0C4DGV4 O43504
PDB IDs		1MHU 2MHU	3MS6 3MSH 5VOK 5X6U 5X6V 5Y38 5Y39 5Y3A 5YK3 6B9X 6EHP 6EHR 6NZD 6U62 6ULG
Enriched GO Terms of Interacting Partners?
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