MT2A and ASS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		MT2A	ASS1
Description		metallothionein 2A	argininosuccinate synthase 1
Image
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Mitochondrial Outer Membrane Lysosome Endoplasmic Reticulum Cytosol Perikaryon Extracellular Exosome Cell Body Fiber
	Molecular Function	Protein Binding Drug Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Argininosuccinate Synthase Activity Protein Binding ATP Binding Toxic Substance Binding Amino Acid Binding Identical Protein Binding
	Biological Process	Cellular Copper Ion Homeostasis Cellular Zinc Ion Homeostasis Response To Metal Ion Detoxification Of Copper Ion Cellular Response To Drug Cellular Response To Interleukin-3 Cellular Response To Erythropoietin Negative Regulation Of Growth Interferon-gamma-mediated Signaling Pathway Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Urea Cycle Citrulline Metabolic Process Argininosuccinate Metabolic Process Kidney Development Liver Development Arginine Biosynthetic Process Aspartate Metabolic Process Acute-phase Response Midgut Development Aging Response To Nutrient Circadian Rhythm Response To Zinc Ion Response To Mycotoxin Response To Estradiol Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Growth Hormone Diaphragm Development Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Ammonium Ion Cellular Response To CAMP Cellular Response To Interferon-gamma Cellular Response To Tumor Necrosis Factor Cellular Response To Glucagon Stimulus Cellular Response To Oleic Acid Cellular Response To Amine Stimulus Cellular Response To Laminar Fluid Shear Stress Cellular Response To Dexamethasone Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion
Pathways		Metallothioneins bind metals Metallothioneins bind metals Interferon gamma signaling	Urea cycle
Drugs		Zinc	L-Arginine L-Aspartic Acid L-Aspartic Acid L-Citrulline L-Citrulline ATP
Diseases			Citrullinemia (CTLN)
GWAS
Interacting Genes		20 interacting genes: ADAMTS4 ARF6 ASS1 BARD1 DHODH ECT2 EOLA1 HMGB1 JMJD1C LAMTOR5 MCPH1 PAXIP1 PRKD1 RCHY1 RIN3 SHBG SPINK7 STOM TNS2 USP25	15 interacting genes: AKTIP APP ARAF ASCC2 ELN JAK2 MLH1 MT2A NUP214 PMPCA PTPN1 STOM TERF1 TERF2 USP4
Entrez ID		4502	445
HPRD ID		08863	04590
Ensembl ID		ENSG00000125148	ENSG00000130707
Uniprot IDs		P02795	P00966 Q5T6L4
PDB IDs		1MHU 2MHU	2NZ2
Enriched GO Terms of Interacting Partners?
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