SETD2 and SPOP

Number of citations of the paper that reports this interaction (PubMedID 28805822)
37

Data Source:
BioGRID (two hybrid)

		SETD2	SPOP
Description		SET domain containing 2, histone lysine methyltransferase	speckle type BTB/POZ protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Alpha-tubulin Binding Metal Ion Binding Histone Methyltransferase Activity (H3-K36 Specific)	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Angiogenesis Morphogenesis Of A Branching Structure Neural Tube Closure Mismatch Repair Regulation Of Transcription, DNA-templated Transcription Elongation From RNA Polymerase II Promoter Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of MRNA Export From Nucleus Viral Process Peptidyl-lysine Trimethylation Peptidyl-lysine Monomethylation Forebrain Development Regulation Of Cytokinesis Positive Regulation Of Interferon-alpha Production Response To Type I Interferon Nucleosome Organization Cell Migration Involved In Vasculogenesis Endodermal Cell Differentiation Mesoderm Morphogenesis Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Stem Cell Development Defense Response To Virus Pericardium Development Embryonic Placenta Morphogenesis Coronary Vasculature Morphogenesis Histone H3-K36 Trimethylation Histone H3-K36 Dimethylation Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Protein Localization To Chromatin	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		PKMTs methylate histone lysines	Hedgehog 'on' state
Drugs
Diseases
GWAS		Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 30275531) HDL cholesterol levels ( 28334899) Huntington's disease progression ( 28642124) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Platelet distribution width ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) White blood cell count ( 27863252) White blood cell count (basophil) ( 27863252)	Prostate cancer ( 23535732)
Interacting Genes		8 interacting genes: ATXN1 CIC H3-4 H3C1 HTT SIAH2 SMAD3 SPOP	69 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRD4 BRMS1 CACUL1 CAPRIN1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GLI3 GMEB1 HCST HMGCS1 INF2 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8
Entrez ID		29072	8405
HPRD ID		11043	16004
Ensembl ID		ENSG00000181555	ENSG00000121067
Uniprot IDs		Q9BYW2	O43791
PDB IDs		2A7O 2MDC 2MDI 2MDJ 4FMU 4H12 5JJY 5JLB 5JLE 5LSS 5LSX 5LSY 5LSZ 5LT6 5LT7 5LT8 5V21 5V22	2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A
Enriched GO Terms of Interacting Partners?
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