SPOP and BRD4

Number of citations of the paper that reports this interaction (PubMedID 28805822)
37

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, affinity chromatography technology)

		SPOP	BRD4
Description		speckle type BTB/POZ protein	bromodomain containing 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Condensed Nuclear Chromosome Nucleus Nucleoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	P53 Binding Chromatin Binding Transcription Coregulator Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Enzyme Binding Lysine-acetylated Histone Binding RNA Polymerase II C-terminal Domain Binding P-TEFb Complex Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Chromatin Organization Protein Phosphorylation Cellular Response To DNA Damage Stimulus Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Positive Regulation Of Histone H3-K36 Trimethylation
Pathways		Hedgehog 'on' state
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Systolic blood pressure ( 30578418)
Interacting Genes		69 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRD4 BRMS1 CACUL1 CAPRIN1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GLI3 GMEB1 HCST HMGCS1 INF2 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	28 interacting genes: C7orf25 C8orf33 CCNT1 CCNT2 CHFR CLDN1 COPS5 GFPT1 GIPC1 H3-3A H3C14 H4-16 H4C14 HNRNPR IL12RB1 LYL1 MESD NELL2 PRPF40A RFC1 RFC2 RFC3 RFC4 RFC5 SPOP TCERG1 TM4SF1 USP17L2
Entrez ID		8405	23476
HPRD ID		16004	10574
Ensembl ID		ENSG00000121067	ENSG00000141867
Uniprot IDs		O43791	A0A024R7H8 O60885
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A	2I8N 2LSP 2MJV 2N3K 2NCZ 2ND0 2ND1 2NNU 2OSS 2OUO 2YEL 2YEM 3MXF 3P5O 3SVF 3SVG 3U5J 3U5K 3U5L 3UVW 3UVX 3UVY 3UW9 3ZYU 4A9L 4BJX 4BW1 4BW2 4BW3 4BW4 4C66 4C67 4CFK 4CFL 4CL9 4CLB 4DON 4E96 4F3I 4GPJ 4HBV 4HBW 4HBX 4HBY 4HXK 4HXL 4HXM 4HXN 4HXO 4HXP 4HXR 4HXS 4IOO 4IOQ 4IOR 4J0R 4J0S 4J3I 4KV1 4KV4 4LR6 4LRG 4LYI 4LYS 4LYW 4LZR 4LZS 4MEN 4MEO 4MEP 4MEQ 4MR3 4MR4 4NQM 4NR8 4NUC 4NUD 4NUE 4O70 4O71 4O72 4O74 4O75 4O76 4O77 4O78 4O7A 4O7B 4O7C 4O7E 4O7F 4OGI 4OGJ 4PCE 4PCI 4PS5 4QB3 4QR3 4QR4 4QR5 4QZS 4UIX 4UIY 4UIZ 4UYD 4WHW 4WIV 4X2I 4XY9 4XYA 4YH3 4YH4 4Z1Q 4Z1S 4Z93 4ZC9 4ZW1 5A5S 5A85 5ACY 5AD2 5AD3 5BT4 5CFW 5COI 5CP5 5CPE 5CQT 5CRM 5CRZ 5CS8 5CTL 5CY9 5D0C 5D24 5D25 5D26 5D3H 5D3J 5D3L 5D3N 5D3P 5D3R 5D3S 5D3T 5DLX 5DLZ 5DW2 5DX4 5E0R 5EGU 5EI4 5EIS 5F5Z 5F60 5F61 5F62 5F63 5FBX 5H21 5HCL 5HLS 5HM0 5HQ5 5HQ6 5HQ7 5I80 5I88 5IGK 5JWM 5KDH 5KHM 5KJ0 5KU3 5LJ1 5LJ2 5LRQ 5LUU 5M39 5M3A 5MKZ 5MLI 5N2M 5NNC 5NND 5NNE 5NNF 5NNG 5O97 5OVB 5OWM 5OWW 5T35 5TI2 5TI3 5TI4 5TI5 5TI6 5TI7 5U28 5U2C 5U2E 5U2F 5UEO 5UEP 5UEQ 5UER 5UES 5UET 5UEU 5UEV 5UEX 5UEY 5UEZ 5UF0 5ULA 5UOO 5UVS 5UVT 5UVU 5UVV 5UVW 5UVX 5UVY 5UVZ 5V67 5VBO 5VBP 5VOM 5VZS 5W55 5WA5 5WMA 5WMD 5WMG 5WUU 5XHY 5XI2 5XI3 5XI4 5Y1Y 5Y8C 5Y8W 5Y8Y 5Y8Z 5Y93 5Y94 5YOU 5YOV 5YQX 5Z1R 5Z1S 5Z1T 5Z5T 5Z5U 5Z5V 5Z8G 5Z8R 5Z8Z 5Z90 5Z9C 5Z9K 6AFR 6AJV 6AJW 6AJX 6AJY 6AJZ 6BN7 6BN8 6BN9 6BNB 6BNH 6BOY 6C7Q 6C7R 6CD4 6CD5 6CIS 6CIY 6CJ1 6CJ2 6CKR 6CKS 6CZU 6CZV 6DJC 6DL2 6DMJ 6DML 6DNE 6DUV 6E4A 6FFD 6FNX 6FO5 6FSY 6FT3 6FT4 6G0O 6G0P 6G0Q 6G0R 6G0S 6HDQ 6HOV 6I7X 6I7Y 6IN1 6MAU 6MH1 6MH7 6MNL 6PRT 6PS9 6PSB 6Q3Y 6Q3Z 6S25 6SE4
Enriched GO Terms of Interacting Partners?
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