SPOP and TCOF1

Number of citations of the paper that reports this interaction (PubMedID 28805822)
37

Data Source:
BioGRID (two hybrid)

		SPOP	TCOF1
Description		speckle type BTB/POZ protein	treacle ribosome biogenesis factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Fibrillar Center Nucleoplasm Nucleolus Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Polymerase I Core Binding RNA Binding Transporter Activity Protein Binding Protein Heterodimerization Activity Scaffold Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Skeletal System Development Regulation Of Translation Neural Crest Formation Neural Crest Cell Development Nucleolar Large RRNA Transcription By RNA Polymerase I
Pathways		Hedgehog 'on' state
Drugs
Diseases			Treacher Collins syndrome
GWAS		Prostate cancer ( 23535732)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908)
Interacting Genes		69 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRD4 BRMS1 CACUL1 CAPRIN1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GLI3 GMEB1 HCST HMGCS1 INF2 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	9 interacting genes: CSNK2A1 CSNK2A2 NOP56 PCNA SPOP SRPK2 TM9SF1 UBC UBTF
Entrez ID		8405	6949
HPRD ID		16004	06026
Ensembl ID		ENSG00000121067	ENSG00000070814
Uniprot IDs		O43791	B4DRA2 E7ETY2 H0Y8Y7 Q13428
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A
Enriched GO Terms of Interacting Partners?
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