SPOP and MYD88

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid)
HPRD (two hybrid)

		SPOP	MYD88
Description		speckle type BTB/POZ protein	MYD88 innate immune signal transduction adaptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Death Receptor Binding Protein Binding Toll-like Receptor Binding Identical Protein Binding Protein Self-association TIR Domain Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Toll Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Type I Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Pathways		Hedgehog 'on' state	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		69 interacting genes: AEN AMOTL2 AR BRD2 BRD3 BRD4 BRMS1 CACUL1 CAPRIN1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GLI3 GMEB1 HCST HMGCS1 INF2 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I UBE2L3 VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	40 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 PELI2 PFKL POLR1C PRDX1 RAC1 SARM1 SIAH1 SIAH2 SMAD3 SPOP STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7
Entrez ID		8405	4615
HPRD ID		16004	03703
Ensembl ID		ENSG00000121067	ENSG00000172936
Uniprot IDs		O43791	A0A0A0MS70 A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 H0Y4G9 Q99836
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A	2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N
Enriched GO Terms of Interacting Partners?
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