LAT and SH3BP2

Number of citations of the paper that reports this interaction (PubMedID 11390470)
26

Data Source:
HPRD (in vitro)

		LAT	SH3BP2
Description		linker for activation of T cells	SH3 domain binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding	Phosphotyrosine Residue Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding
	Biological Process	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation	Signal Transduction Positive Regulation Of Signal Transduction
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases			Cherubism
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Huntington's disease progression ( 28642124) Multiple sclerosis ( 24076602)
Interacting Genes		33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2	24 interacting genes: ABL1 ARHGAP10 DBNL ERBB2 FGFR1 FLT3 FYN GRB2 LAT LCK NSD2 PDLIM7 PLCG1 PLCG2 SH3KBP1 STAT3 SYK TF TNKS2 VAV1 VAV2 VAV3 YWHAQ ZAP70
Entrez ID		27040	6452
HPRD ID		03832	03657
Ensembl ID		ENSG00000213658	ENSG00000087266
Uniprot IDs		A0A024QZD6 O43561	A0A384N6E5 P78314
PDB IDs			2CR4 3TWR
Enriched GO Terms of Interacting Partners?
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